Table 1.
In vitro effects of crude hydroalcoholic extract (TV) and essential oil of T. vulgare (TV-EO) against S. mansoni adult worms.
Groups | Incubation period (h) | Separated worms (%)a | Dead worms (%)a | Decrease in motor activity (%)a | Worms with tegumental alteration (%)a | ||
---|---|---|---|---|---|---|---|
Slight | Significant | Partial | Extensive | ||||
Controlb | 24 | 0 | 0 | 0 | 0 | 0 | 0 |
72 | 0 | 0 | 0 | 0 | 0 | 0 | |
0.5% DMSO | 24 | 0 | 0 | 0 | 0 | 0 | 0 |
72 | 0 | 0 | 0 | 0 | 0 | 0 | |
PZQc | 24 | 0 | 100 | 0 | 100 | 0 | 100 |
72 | 0 | 100 | 0 | 100 | 0 | 100 | |
TV | |||||||
10 μg/mL | 24 | 0 | 0 | 0 | 0 | 0 | 0 |
72 | 0 | 0 | 0 | 0 | 0 | 0 | |
50 μg/mL | 24 | 0 | 0 | 0 | 0 | 0 | 0 |
72 | 0 | 100 | 0 | 100 | 0 | 100 | |
100 μg/mL | 24 | 0 | 0 | 0 | 0 | 0 | 0 |
72 | 100 | 100 | 0 | 100 | 100 | 100 | |
200 μg/mL | 24 | 0 | 100 | 0 | 100 | 0 | 100 |
72 | 100 | 100 | 0 | 100 | 0 | 100 | |
TV-EO | |||||||
10 μg/mL | 24 | 0 | 0 | 0 | 0 | 0 | 0 |
72 | 50 | 0 | 0 | 100 | 0 | 0 | |
50 μg/mL | 24 | 0 | 0 | 0 | 0 | 0 | 0 |
72 | 100 | 0 | 0 | 100 | 0 | 0 | |
100 μg/mL | 24 | 100 | 0 | 0 | 0 | 0 | 0 |
72 | 100 | 0 | 0 | 100 | 0 | 0 | |
200 μg/mL | 24 | 100 | 100 | 0 | 100 | 0 | 0 |
72 | 100 | 100 | 0 | 100 | 0 | 0 |
aPercentages relative to the 20 worms investigated. bRPMI 1640. cTested at concentration of 10 μM.