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. 2014 Feb 19;9(2):e88818. doi: 10.1371/journal.pone.0088818

Figure 3. ENT1 null mice present with significantly reduced thickness of trabecular bone within the lumbar vertebral body by micro computerized tomography (microCT).

Figure 3

Representative cross section through the vertebral body of a lumbar spine in (A) wild-type and (B) ENT1 null mice. Scale bar = 1 mm. It was noted that ENT1 null mice have reduced trabecular bone thickness and reduced intervertebral space. Magnified view of the trabecular bone within the lumbar vertebral vertebra of (C) wild-type and (D) ENT1 null mice. Scale bar = 1 mm. E Trend for a reduction in the trabecular bone volume fraction (BV/TV), which is equal to the percentage of the tissue space that is occupied by bone within the lumbar vertebral body, of ENT1 null mice compared to wild-type mice. F Trabecular thickness (Tb.Th) or the average thickness of the trabecular struts was reduced in ENT1 null mice compared to wild-type littermates. G Trabecular number (Tb.N) or a measure of the number of trabeculae within a given space was similar between wild-type and ENT1 null mice. H Trabecular separation (Tb.S) or the average spacing between adjacent trabeculae was similar between ENT1 null and wild-type mice. n = 4–5 per genotype. *P<0.05 by Student’s two-tailed t test. All data are presented as mean ± SEM.