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. 2014 Feb 19;9(2):e88818. doi: 10.1371/journal.pone.0088818

Figure 4. ENT1 null mice have reduced trabecular bone volume fraction, thickness and number and increased trabecular separation in the femur by micro computerized tomography (microCT).

Figure 4

Representative cross section through the trabecular bone of the distal femoral metaphysis of the femur of (A) wild-type and (B) ENT1 null mice. Scale bar = 1 mm. C Reduced trabecular bone volume fraction (BV/TV), which is equal to the percentage of the tissue space that is occupied by bone within the lumbar vertebral body, of ENT1 null mice compared to wild-type mice. D Trabecular thickness (Tb.Th) or the average thickness of the trabecular struts was reduced in ENT1 null mice compared to wild-type littermates. E Trabecular number (Tb.N) or a measure of the number of trabeculae within a given space was decreased in ENT1 null mice relative to wild-type mice. F Trabecular separation (Tb.S) or the average spacing between adjacent trabeculae was reduced in ENT1 null compared to wild-type mice. n = 3 per genotype. *P<0.05 by Student’s two-tailed t test. All data are presented as mean ± SEM.