Table 5. Adjusted odds ratios for ischaemic stroke risk.
| Age and gender-adjusted | Serum iron-adjusted | |||||
| N | Odds Ratio | p value | N | Odds Ratio | p value | |
| Age | — | — | — | 419 | 1·02 (1·00, 1·03) | 0·13 |
| Gender | — | — | — | 419 | 1·40 (0·75, 2·58) | 0·29 |
| Smoking | 497 | 1·08 (0·62, 1·91) | 0·78 | 419 | 0·94 (0·52, 1·70) | 0·84 |
| Hypertension | 495 | 1·32 (0·65, 2·67) | 0·44 | 417 | 1·27(0·60, 2·68) | 0·54 |
| Diabetes | 497 | 3·34 (0·61, 18·2) | 0·16 | 419 | 3·10 (0·54, 17·6) | 0·2 |
| AF and other arrythmias | 497 | 1·05 (0·12, 9·21) | 0·96 | 419 | 1·07 (0·12, 9·56) | 0·95 |
| Hypercholesterolemia | 496 | 0·78 (0·09, 6·65) | 0·82 | 418 | 1·24 (0·14, 10·6) | 0·85 |
| Myocardial infarction (MI) | 497 | 8·86 (1·41, 55·5) | 0·02 | 419 | 22·6 (2·26, 226·7) | 0·008 |
| Brain abscess | 497 | 0·98 (0·39, 2·46) | 0·97 | 419 | 0·88 (0·33, 2·35) | 0·02 |
| Migraines | 496 | 0·87 (0.49, 1·56) | 0·43 | 418 | 0·89 (0·49, 1·62) | 0·71 |
| Venous thromboemboli (VTE) | 497 | 0·77 (0·22, 2·67) | 0·68 | 419 | 0·53 (0·11, 2·34) | 0·4 |
| Ever transfused | 487 | 1·28 (0·53, 3·12) | 0·58 | 413 | 1·46 (0·60, 3·58) | 0·41 |
| On iron treatment (oral) | 489 | 1·28 (0·70, 2·34) | 0·41 | 413 | 1·14 (0·60, 2·15) | 0·68 |
| Ever used intravenous iron | 482 | 1·41 (0·39, 5·17) | 0·6 | 407 | 1·31 (0·35, 4·85) | 0·69 |
| Ever used tranexamic acid | 482 | 0·99 (0·21, 4·6) | 0·99 | 407 | 1·22 (0·25, 5·98) | 0·8 |
| Ever used female hormones | 480 | 1·41 (0·64, 3·14) | 0·4 | 405 | 1·47 (0·64, 3·40) | 0·37 |
| Oxygen saturation erect (SaO2)† | 471 | 0·98 (0·93, 1·02) | 0·28 | 398 | 0·96 (0·92, 1·01) | 0·085 |
| Haemoglobin (g/dl) | 464 | 1·00 (0·99, 1·02) | 0·38 | 410 | 0·98 (0·91, 1·05) | 0·62 |
| Platelets | 465 | 1·00 (1·00, 1·00) | 0·67 | 415 | 1·00 (1.00, 1.00) | 0·48 |
| Serum iron † | 419 | 0·96 (0·92, 1·00) | 0·036 | — | — | — |
| Transferrin saturation index (TfSI) | 420 | 0·99 (0·97, 1·01) | 0·17 | 418 | 1·00 (0·95, 1·06) | 0·93 |
| Ferritin | 242 | 1·00 (0·99, 1·01) | 0·91 | 236 | 1·00 (0·99, 1·01) | 0·74 |
| C-reactive protein | 310 | 1·03 (1·00, 1·07) | 0·06 | 292 | 1·03 (0·99, 1·06) | 0·1 |
| Prothrombin time | 439 | 1·08 (0·96, 1·21) | 0·2 | 394 | 1·02 (0·87, 1·20) | 0·83 |
| Activated partial thromboplastin time | 435 | 0·97 (0·87, 1·07) | 0·54 | 391 | 1·00 (0·90, 1·11) | 0·97 |
| Thrombin time | 421 | 1·14 (0·97, 1·38) | 0·11 | 379 | 1·13 (0·96, 1·34) | 0·14 |
| Fibrinogen | 439 | 1·24 (1·00, 1·53) | 0·048 | 393 | 1·16 (0·91, 1·47) | 0·25 |
| Factor VIII | 280 | 1·45 (0·95, 2·30) | 0·089 | 263 | 1·24 (0·78, 1·96) | 0·36 |
| von Willebrand Factor | 202 | 1·09 (0·97, 1·23) | 0·14 | 188 | 0·99 (0·70, 1·40) | 0·95 |
| Pulmonary artery pressure (systolic) | 262 | 0·99 (0·94, 1·04) | 0·71 | 221 | 0·97 (0·92, 1·03) | 0·39 |
| Pulmonary artery pressure (diastolic) | 262 | 0·96 (0·88, 1·06) | 0·45 | 221 | 0·96 (0·87, 1·06) | 0·44 |
| Pulmonary artery pressure (mean) | 259 | 0·96 (0·89, 1·04) | 0·3 | 218 | 0·94 (0·86, 1·03) | 0·17 |
| Series indicator | 497 | 0·79 (0·54, 1·18) | 0·23 | 419 | 0·73 (0·48, 1·10) | 0·13 |
Full list of age/gender, and serum iron-adjusted odds ratios for ischaemic stroke risk for the specified variable, where an inverse association with stroke risk is indicated by an odds ratio <1. N: number of datasets available. CI, confidence intervals, AF, atrial fibrillation. Pseudo r2 indicates the proportion of stroke variance explained by age, gender, and the specified variable. P values were calculated by the non parametric Wald test which does not assume independence of variables. † Quadratic regression plots for stroke risk versus serum iron or SaO2 presented in Figure S1. Note p = 0.047 significant at FDR = 0.05 level.