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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Ultrasound Med. 2013 Sep;32(9):1593–1600. doi: 10.7863/ultra.32.9.1593

Table 3.

Predictive Efficiency of First-Trimester Parameters for Pre-Eclampsia

Marker AUC
(95% CI)		 Sensitivity
10% FPR		 Sensitivity
20% FPR
Maternal Characteristics Alone 0.78
(0.71-0.85)		 50% 62%
ADAM12 Alone 0.58
(0.50-0.67)		 12% 30%
PAPP-A Alone 0.64
(0.57-0.72)		 18% 32%
Uterine Artery Doppler Alone 0.49
(0.41-0.56)		 5% 16%
ADAM12 +PAPP-A + Uterine Artery
Doppler Alone 		0.64
(0.57-0.72)		 22% 42%
Maternal Characteristics + ADAM12 0.78
(0.70-0.85)		 50% 62%
Maternal Characteristics + PAPP-A 0.79
(0.72-0.86)		 48% 64%
Maternal Characteristics + Uterine
Artery Doppler 		0.77
(0.69-0.86)		 52% 64%
Maternal Characteristics + ADAM12 +
PAPP-A 		0.79
(0.71-0.86)		 50% 70%
Maternal Characteristics + ADAM12 +
Uterine Artery Doppler 		0.78
(0.70-0.86)		 52% 62%
Maternal Characteristics + ADAM12 +
PAPP-A + Uterine Artery Doppler 		0.79
(0.71-0.87)		 50% 75%
*

Maternal characteristics: African American race, body mass index, history of chronic hypertension, history of pre-gestational diabetes