Table 5.
Stability of emtricitabinein rat plasma (n = 6).
| Sample condition | Spiked concentration (μg/mL) | Mean determined concentration (µg/mL) |
Accuracy (%) |
|---|---|---|---|
| Bench-top stability♦ | 0.1 | 0.096 | 96.0 |
| 0.8 | 0.783 | 97.87 | |
| 1.6 | 1.571 | 98.18 | |
| 2.0 | 1.944 | 97.20 | |
|
| |||
| Freeze-thaw stability♣ | 0.1 | 0.099 | 99.00 |
| 0.8 | 0.795 | 99.37 | |
| 1.6 | 1.582 | 98.87 | |
| 2.0 | 1.995 | 99.75 | |
|
| |||
| One-week stability▲ | 0.1 | 0.093 | 93.00 |
| 0.8 | 0.746 | 93.25 | |
| 1.6 | 1.517 | 94.81 | |
| 2.0 | 1.911 | 95.55 | |
♦Exposed at ambient temperature (25°C) for 4 h.
♣After three freeze-thaw cycles.
▲Stored at −16°C.