Table 6.

Pharmacokinetic parameters of free emtricitabine and emtricitabine NPs at a dose of 15 mg/kg/rat.

Pharmacokinetic parameters	Free emtricitabine	Emtricitabine NPs
C max⁡ (µg/mL)	1.696 ± 0.017	1.934 ± 0.041
t max⁡ (h)	2.0 ± 0.006	16 ± 0.031
t 1/2 (h)	9.366 ± 0.580	32.099 ± 2.194
AUC0–∞ (µg/mL∗h)	14.835 ± 0.450	238.667 ± 10.315
AUMC0–∞ (µg/mL∗h)	178.32 ± 15.095	22156.689 ± 1243.02
K e (1/h)	0.0741 ± 0.004	0.0215 ± 0.0013
MRT	12.0 ± 0.670	94.307 ± 1.950

Data presented as mean ± standard deviation (n = 6).