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. Author manuscript; available in PMC: 2014 Nov 29.
Published in final edited form as: Oncogene. 2013 Jul 1;33(22):2909–2917. doi: 10.1038/onc.2013.247

Figure 6.

Figure 6

Mechanism of action model for KLF8/FAK-MMP14 signaling loop in promotion of invasion and metastasis. KLF8 directly activates MMP14 promoter. On the other hand, KLF8 promotes nuclear presence of β-catenin presumably by repressing E-cadherin expression and upregulates TCF1 expression resulting in β-catenin/TCF1-dependent activation of the MMP14 promoter. The KLF8- upregulated MMP14 protein is enriched by FAK on the cell surface where it catalyzes the activation of MMP2 and subsequent ECM degradation required for invasion and metastasis.