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. 2014 Feb 19;9(2):e88549. doi: 10.1371/journal.pone.0088549

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© 2014 Tomonoh et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Sample traces recorded from 10-week old Y284C heterozygous CA1 neurons in response to voltage steps to the indicated potential. (B, C) Voltage-dependence of M-current activation in wildtype (○), heterozygous (), and homozygous (•) Y284C mice at 4 weeks (B) and 10 weeks (C). Whole-cell perforated patched CA1 neurons were stepped to the indicated potential and back to −20 mV to determine tail current amplitudes. Significant I _M reductions were seen in Y284C homozygotes at 4 and 10 weeks, and in heterozygotes at 10 weeks at −60 mV (P<0.05, Tukey-Kramer test).

Inline graphic — (A) Sample traces recorded from 10-week old Y284C heterozygous CA1 neurons in response to voltage steps to the indicated potential. (B, C) Voltage-dependence of M-current activation in wildtype (○), heterozygous (), and homozygous (•) Y284C mice at 4 weeks (B) and 10 weeks (C). Whole-cell perforated patched CA1 neurons were stepped to the indicated potential and back to −20 mV to determine tail current amplitudes. Significant I _M reductions were seen in Y284C homozygotes at 4 and 10 weeks, and in heterozygotes at 10 weeks at −60 mV (P<0.05, Tukey-Kramer test).