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. Author manuscript; available in PMC: 2014 Jun 7.
Published in final edited form as: Circ Res. 2013 Mar 21;112(12):1592–1601. doi: 10.1161/CIRCRESAHA.112.300626

Figure 6. Delivery of miR-144 oligonucleotides significantly reduces liver ABCA1 expression and HDL levels in mice.

Figure 6

(A) qRT-PCR analysis of ABCA1 and ABCG1 expression from mouse livers treated with miR-144 mimics. Data are the mean±SEM from 6 mice per group. *Significantly different from mice injected with non-targeting control mimic (Con-miR) conjugated particles. P≤ 0.05. (B) Analysis of hepatic gene expression 6 days after injection of Con-miR or miR-144. Western blot analysis of liver tissue from three representative mice per group. Quantification analysis is shown in the right panel. Data are the mean±SEM from 6 mice per group. *Significantly different from mice injected with Con-miR conjugated particles. P≤ 0.05. (C) Total cholesterol (left panel), HDL cholesterol (middle panel) and TG (right panel) levels in mice treated with Con-miR or miR-144 mimics (n=6). *Significantly different from mice injected with non-targeting Con-miR conjugated particles. P≤ 0.05. (D) Lipoprotein profile from mice treated with Con-miR or miR-144 mimics (n=6). Cholesterol distribution across plasma fractions was analyzed by FPLC.