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. Author manuscript; available in PMC: 2014 Feb 20.
Published in final edited form as: Cell. 2013 Jul 18;154(2):325–336. doi: 10.1016/j.cell.2013.06.039

Figure 2.

Figure 2

Early deletion of LSD1 with Foxg1-Cre causes massive reduction in OR gene expression and developmental arrest at a differentiation stage synchronous to the onset of OR transcription.

(A) mRNA-seq RPKM for each Refseq OR in mouse genome from E18.5 MOE sample. Each spoke of a given color is the value for that OR in MOE of that genotype (red: Foxg1-Cre; LSD1flox/+; green: Foxg1-Cre; Lsd1flox/flox). External doughnut represents relative chromosomal location of each OR gene. Summary boxplot is shown within Circos plot; student’s paired t-test used for significance testing.

(B) RPKM values of the 2 known transcriptional activators of OR genes in the LSD1 heterozygote and knockout.

(C-F) Chromogenic ISH for developmental markers in LSD1 heterozygote (top panels) and knockout (bottom panels), respectively: Neurod1, GAP43, NCAM1, OMP.

(G) IF for Adcy3 at same embryonic stage, DAPI nuclear stain is shown in blue. See also Figure S2.