Table 5. Cox Proportional Hazards Models of Mortality by Genotype in ARDS Cases (n = 566).^± .

	Crude HR (95% CI)	P	Adjusted HR*(95% CI)	P	FDR_q
ADIPOQ
rs266729	0.60 (0.30–1.21)	0.16	0.71 (0.34–1.45)	0.34	0.37
rs822387	1.07 (0.27–4.30)	0.93	1.95 (0.48–7.91)	0.35	0.37
rs864265	0.27 (0.038–1.92)	0.19	0.23 (0.032–1.64)	0.14	0.27
rs2082940	4.09 (2.16–7.74)	<0.0001	2.61 (1.36–5.00)	0.004	0.02
rs16861194	—**	0.97	—**	0.98	0.68
ADIPOR1
rs7539542	1.18 (0.78–1.79)	0.44	1.46 (0.94–2.27)	0.09	0.27
ADIPOR2
rs1029629	0.87 (0.54–1.39)	0.56	0.96 (0.59–1.57)	0.87	0.68
rs1044471	0.98 (0.71–1.36)	0.91	0.92 (0.66–1.29)	0.64	0.57
rs16928751	2.12 (0.94–4.78)	0.07	1.78 (0.77–4.09)	0.17	0.27

^±Models shown represent recessive inheritance pattern.

*Also included in the model: age, BMI, APACHE, trauma, cirrhosis, diabetes.

**HR could not be calculated because only 0.7% of subjects genotyped at this locus had the homozygous variant genotype.

HR = hazard ratio; CI = confidence interval; FDR_q = false discovery rate q-value.