. 2014 Mar;28(3):1098–1112. doi: 10.1096/fj.13-235044

Table 2.

Time course of differential cell counts from bronchoalveolar lavage fluid after 4 mg/kg V₂O₅

Strain	Treatment	Day	Macrophages	Epithelial cells	Neutrophils	Eosinophils	Lymphocytes	Monocytes
B6	PBS	1	74,568 ± 6335	2851 ± 923	269 ± 127	175 ± 65	323 ± 180	29 ± 29
	V₂O₅	1	136,850 ± 17,242^*	2591 ± 606	17,795 ± 7363^*	3490 ± 1519	796 ± 392	354 ± 122
D2	PBS	1	53,608 ± 8521	1227 ± 438	639 ± 318	232 ± 178	328 ± 263	216 ± 129
	V₂O₅	1	48,573 ± 9115^#	3375 ± 789	87,191 ± 18,880^*^,#	7806 ± 2917^*	1120 ± 409^*	4435 ± 2543
B6	PBS	2	94,982 ± 6775	704 ± 235	458 ± 299	290 ± 186	632 ± 442	114 ± 73
	V₂O₅	2	144,811 ± 20,196	1252 ± 407	26,553 ± 6536^*	4434 ± 2681	632 ± 195	391 ± 204
D2	PBS	2	47,055 ± 4249	2175 ± 413	2088 ± 1994	79 ± 52	675 ± 388	116 ± 81
	V₂O₅	2	120,126 ± 36,488^*	4131 ± 2064^#	98,993 ± 19,045^*^,#	7451 ± 1647^*	2381 ± 817^*^,#	3793 ± 1118^*^,#
B6	PBS	4	87,693 ± 10,628	600 ± 155	43 ± 28	108 ± 60	626 ± 200	94 ± 94
	V₂O₅	4	157,155 ± 14,987	622 ± 358	9938 ± 2522^*	2056 ± 1049	2211 ± 1306	517 ± 292
D2	PBS	4	42,701 ± 1274	1879 ± 483	147 ± 67	0 ± 0	225 ± 63	47 ± 47
	V₂O₅	4	323,328 ± 19,661^*^,#	3422 ± 1489	54,751 ± 22,372^*^,#	5163 ± 1395^*^,#	3334 ± 964^*	2085 ± 883
B6	PBS	6	87,914 ± 10,786	704 ± 286	190 ± 97	110 ± 79	342 ± 165	205 ± 100
	V₂O₅	6	161,864 ± 11,882^*	447 ± 220	3575 ± 1459^*	1185 ± 375^*	1552 ± 347	1377 ± 1068^*
D2	PBS	6	55,915 ± 9388	3205 ± 1117^#	21 ± 21	32 ± 32	425 ± 222	90± 74
	V₂O₅	6	148,895 ± 18,494^*	2567 ± 653	3826 ± 1102^*	1108 ± 174^*^,#	4317 ± 1110^*^,#	1430 ± 276^*
B6	PBS	8	76,569 ± 8710	1100 ± 402	0 ± 0	106 ± 106	297 ± 184	261 ± 31
	V₂O₅	8	174,992 ± 14,137^*	1458 ± 301	25,297 ± 12,328^*	3167 ± 890	1000 ± 355	2419 ± 1001^*
D2	PBS	8	64,423 ± 7863	2654 ± 653	685 ± 427	125 ± 77	238 ± 238	0 ± 0
	V₂O₅	8	208,504 ± 31,004^*	2257 ± 1073	82,521 ± 30,037^*^,#	5211 ± 3282	3429 ± 1244^*^,#	2007 ± 865
B6	PBS	10	73,567 ± 6493	838 ± 289	60 ± 60	0 ± 0	89 ± 62	89 ± 89
	V₂O₅	10	154,389 ± 17,799^*	1500 ± 655	26,187 ± 9583^*	1574 ± 771	2283 ± 538^*	2505 ± 838^*
D2	PBS	10	48,852 ± 6635	6939 ± 2551^#	285 ± 172	63 ± 42	111 ± 61	0 ± 0
	V₂O₅	10	278,422 ± 41,807^*^,#	12,121 ± 10,148^*^,#	38,392 ± 12,957^*	5413 ± 1771^*	^*3016 ± 1108	763 ± 420^#
B6	PBS	12	64,322 ± 7381	519 ± 261	578 ± 578	0 ± 0	1242 ± 576	839 ± 477
	V₂O₅	12	160,214 ± 11,386	329 ± 221	7497 ± 6491^*	467 ± 467	1211 ± 315	699 ± 319
D2	PBS	12	47,679 ± 7410	2319 ± 794	492 ± 389	46 ± 46	46 ± 46	44 ± 44
	V₂O₅	12	463,124 ± 81,903^*^,#	2460 ± 972^#	23,143 ± 11,122^*^,#	4302 ± 1360^*^,#	7199 ± 2540^*^,#	2987 ± 1111
B6	PBS	14	71,730 ± 9969	539 ± 178	21 ± 21	0 ± 0	350 ± 103	217 ± 115
	V₂O₅	14	177,479 ± 17,122^*	1072 ± 522	2270 ± 1326	1440 ± 883	1740 ± 429	1625 ± 785
D2	PBS	14	47,969 ± 7509	4347 ± 1282^#	502 ± 180	128 ± 91	698 ± 599	419 ± 405
	V₂O₅	14	357,179 ± 58,672^*^,#	19,975 ± 11,651	16,721 ± 14,213^*^,#	4451 ± 1638^*^,#	2819 ± 1474^*^,#	1668 ± 1028
B6	PBS	21	75,254 ± 8887	381 ± 151	54 ± 54	0 ± 0	713 ± 330	385 ± 149
	V₂O₅	21	139,441 ± 16,420^*	1269 ± 506	189 ± 71	328 ± 199	2217 ± 459	932 ± 189
D2	PBS	21	45,451 ± 2588^#	1679 ± 614	81 ± 43	35 ± 35	284 ± 85	281 ± 96
	V₂O₅	21	187,834 ± 12,863^*^,#	2599 ± 798	75 ± 75	421 ± 234	3672 ± 1463^*^,#	1024 ± 309
B6	PBS	28	41,733 ± 9489	1250 ± 270	21 ± 21	0 ± 0	121 ± 95	0 ± 0
	V₂O₅	28	69,504 ± 13,042	1679 ± 641	0 ± 0	0 ± 0	256 ± 162	435 ± 225
D2	PBS	28	55,419 ± 8060	1173 ± 235	0 ± 0	0 ± 0	223 ± 153	60 ± 60
	V₂O₅	28	139,519 ± 32,980^*^,#	5847 ± 1564^*^,#	0 ± 0	0 ± 0	2472 ± 2472	494 ± 494
B6	PBS	42	38,427 ± 2234	488 ± 488	94 ± 63	133 ± 94	233 ± 233	0 ± 0
	V₂O₅	42	38,696 ± 3080	2688 ± 1930	94 ± 55	413 ± 413	381 ± 249	229 ± 144
D2	PBS	42	48,808 ± 4006	2977 ± 1163	44 ± 44	46 ± 46	0 ± 0	0 ± 0
	V₂O₅	42	69,867 ± 14,870^#	2867 ± 816	146 ± 94	50 ± 50	48 ± 48	148 ± 94
B6	PBS	56	46,079 ± 5268	6777 ± 4116	83 ± 49	29 ± 29	110 ± 66	46 ± 46
	V₂O₅	56	46,969 ± 8680	7825 ± 4610	0 ± 0	460 ± 460	335 ± 211	35 ± 35
D2	PBS	56	36,596 ± 3878	3496 ± 925	31 ± 31	0 ± 0	308 ± 120	194 ± 117
	V₂O₅	56	101,039 ± 16,545^*^,#	6528 ± 1271	0 ± 0	0 ± 0	200 ± 200	567 ± 186^*^,#
B6	PBS	84	57,538 ± 3895	6233 ± 168	338 ± 84	96 ± 55	296 ± 51	0 ± 0
	V₂O₅	84	56,108 ± 9472	5238 ± 1155	256 ± 60	140 ± 55	133 ± 133	0 ± 0
D2	PBS	84	57,629 ± 3505	5929 ± 214	96 ± 55	0 ± 0	96 ± 55	0 ± 0
	V₂O₅	84	87,571 ± 6865^*^,#	15,254 ± 3958^*^,#	1150 ± 197^*^,#	617 ± 98^*^,#	408 ± 307	0 ± 0
B6	PBS	112	48,846 ± 1123	5596 ± 200	96 ± 55	375 ± 115	88 ± 51	0 ± 0
	V₂O₅	112	44,906 ± 7175	7104 ± 747	173 ± 78	431 ± 192	510 ± 210	0 ± 0
D2	PBS	112	52,733 ± 1578	8125 ± 188	308 ± 53	517 ± 48	817 ± 221	0 ± 0
	V₂O₅	112	73,142 ± 7285^*^,#	17,126 ± 2099^*^,#	943 ± 184^*^,#	858 ± 347	431 ± 250	0 ± 0

P < 0.05 vs. 0 mg/kg V₂O₅ within strain;

P < 0.05 vs. B6 within dose.