Table 3.

Fold up- or down-regulation of V₂O₅-induced fibrosis-related genes in DBA/2J (D2) compared to C57BL/6J (B6) mice

Gene	Description	d 10	d 21
Acta2	Actin, α 2, smooth muscle	−2.84	1.52
Bcl2	B cell leukemia/lymphoma 2	−3.47	1.49*
Bmp7	Bone morphogenetic protein 7	−2.25	1.19
Cav1	Caveolin 1, caveolae protein	−2.77	1.89*
Ccl11	Chemokine (C-C motif) ligand 11 (eotaxin)	−1.41	3.75*
Ccl12	Chemokine (C-C motif) ligand 12	−2.29	1.49
Ccl3	Chemokine (C-C motif) ligand 3 (Mip1-α)	−2.90	−1.33
Ccr2	Chemokine (C-C motif) receptor 2 (Mcp1 receptor)	−4.35*	−1.32
Col1a2	Collagen, type I, α 2	1.78	1.90*
Ctgf	Connective tissue growth factor	1.12	2.38*
Cxcr4	Chemokine (C-X-C motif) receptor 4	−2.77	1.50*
Dcn	Decorin	−2.26	−1.35
Edn1	Endothelin 1	−3.47	1.88*
Egf	Epidermal growth factor	−2.27	1.19
Eng	Endoglin	−3.49*	1.49*
Fasl	Fas ligand (TNF superfamily, member 6)	−3.74	2.94*
Grem1	Gremlin 1	−2.88	1.15
Hgf	Hepatocyte growth factor	−2.19	−1.33
Il13ra2	Interleukin 13 receptor α 2	−2.25	−1.11
Il1a	Interleukin 1 α	−4.62*	2.36*
Il1b	Interleukin 1 β	−11.06*	1.19
Il4	Interleukin 4	−2.21	1.15
Il5	Interleukin 5	−2.19	−1.09
Inhbe	Inhibin β E	−3.55	−1.69
Itga1	Integrin α 1	−2.86*	−1.35
Itga2	Integrin α 2	−2.91	−1.34
Itgb3	Integrin β 3	−2.22	1.20
Itgb5	Integrin β 5	−3.47	−1.68*
Jun	Jun oncogene	−3.48*	−1.33
Lox	Lysyl oxidase	−3.49*	−1.34
Mmp13	Matrix metallopeptidase 13 (interstitial collagenase)	−2.60	1.20
Mmp14	Matrix metallopeptidase 14 (membrane-inserted)	−2.26	−1.34
Mmp3	Matrix metallopeptidase 3 (stromelysin 1)	−7.12*	−3.41*
Mmp8	Matrix metallopeptidase 8 (neutrophil collagenase)	−14.61*	1.49*
Mmp9	Matrix metallopeptidase 9 (type IV collagenase)	−5.91*	−1.07
Myc	Myelocytomatosis oncogene	−2.31	1.50*
Plat	Plasminogen activator, tissue	−3.65	1.88*
Plau	Plasminogen activator, urokinase	−2.21	−2.11*
Serpina1a	Serine (or cysteine) peptidase inhibitor, clade A, member 1A	−2.19	2.55*
Serpine1	Serine (or cysteine) peptidase inhibitor, clade E, member 1	−2.91	−1.08
Smad2	SMAD family member 2	−2.19	1.50
Smad6	SMAD family member 6	−4.40*	1.51*
Smad7	SMAD family member 7	−5.52*	1.17
Snai1	Snail homolog 1 (Drosophila)	−4.42*	1.50
Tgfb1	Transforming growth factor, β 1	−2.20	−1.34
Tgfb3	Transforming growth factor, β 3	−2.76	−1.06
Tgif1	TGFB-induced factor homeobox 1	−2.26	−2.69*
Thbs2	Thrombospondin 2	−2.18	1.50*
Timp4	Tissue inhibitor of metalloproteinase 4	−1.73	2.38

^*P < 0.05 for V₂O₅-treated D2 mice vs. V₂O₅-treated B6 mice.