Table 3. Comparison of characteristics of subgroups of FBXW7-positive patients and a control group of CRC patients tested negative for a FBXW7 mutation.
| Characteristic | Non-CRC FBXW7 pos (N = 10) (%) | CRC FBXW7 pos (N = 7) (%) | CRC FBXW7 neg (N = 41) (%) |
| Female | 6 (60) | 2 (29) | 23 (56) |
| White | 8 (80) | 5 (71) | 27 (66) |
| Median Age | 59 (15–74) | 57 (36–67) | 52 (23–74) |
| >3 metastatic sites | 1 (10) | 1 (14) | 6 (15) |
| Liver metastasis | 3 (30) | 5 (71) | 33 (80) |
| Lung metastasis | 5 (50) | 6 (86) | 32 (78) |
| KRAS mutation | 0 (0)a | 6 (86)a | 33 (80) |
| TP53 mutation | 6 (60) | 4 (57) | 17 (41) |
| APC mutation | 0 (0)b | 3/5 (60)b | 16/24 (67) |
| PIK3CA mutation | 1 (10) | 1 (14) | 8 (20) |
a
p = 0.0006;
b
p = 0.022 (Fisher exact test).
CRC: colorectal cancer.