| PI Mar |
– |
– |
– |
– |
| PI Min |
L10I |
5 |
4.7 |
L10I/V occur in 5–10% of untreated persons. |
|
Q58E |
1 |
0.9 |
Q58E associated with decreased susceptibility to TPV/r and possibly other PIs. |
|
A71T/V |
16/12 |
14.9/11.2 |
A71T/V occur in 2–3% of untreated persons. |
| NRTI |
M41L |
1 |
0.9 |
M41L usually occurs with T215Y. confer high-level resistance to AZT and d4T and low level resistance to ddI, ABC, and TDF. |
|
D67H |
2 |
1.9 |
D67H is a highly unusual mutation at this position. |
|
D67N |
3 |
2.8 |
D67N contributes resistance to AZT and d4T. |
|
T69A/N |
1/2 |
0.9/1.9 |
T69N/S/A/I are NRTI-selected mutations. |
|
K70N |
1 |
0.9 |
K70Q/N/S/T are rare NRTI-selected mutations. |
|
K70R |
3 |
2.8 |
K70R causes intermediate resistance to AZT and low-level resistance to d4T and TDF. |
|
M184L |
1 |
0.9 |
M184L is a unusual mutation at this position. |
|
M184V |
2 |
1.9 |
M184V/I cause high-level resistance to 3TC and FTC and low-level resistance to ddI and ABC. |
|
L210W |
1 |
0.9 |
L210W contributes resistance to each of the NRTIs except 3TC and FTC. It usually occurs with the mutations M41L and T215Y. |
|
T215F/Y |
2/3 |
1.9/2.8 |
T215F causes AZT and D4T resistance and reduces susceptibility to ABC, ddI, and TDF particularly in combination with M41L and L210W. T215F occurs more commonly (than T215Y) with Type II TAMs. |
|
K219E |
3 |
2.8 |
K219Q/E decrease AZT and probably d4T susceptibility when present with K70R or T215Y/F. |
| NNRTI |
A98G |
2 |
1.9 |
A98G reduces NVP and EFV susceptibility by about 5-fold and 3-fold, respectively. |
|
K101E |
2 |
1.9 |
K101E causes intermediate resistance to NVP and low-level resistance to EFV, ETR, and RPV. |
|
K103N |
13 |
12.1 |
K103N causes high-level resistance to NVP, and EFV. |
|
V108I |
2 |
1.9 |
V108I reduces NVP and EFV susceptibility. |
|
V179D/E |
2/2 |
1.9/1.9 |
V179D/E occur in ∼1% of NNRTI-naive individuals and alone reduce NVP and EFV susceptibility. |
|
Y181C |
9 |
8.4 |
Y181C causes high-level resistance to NVP, ∼2-fold decreased susceptibility to EFV, and ∼5-fold decreased susceptibility to ETR and RPV. |
|
G190A |
2 |
1.9 |
G190A causes high level resistance to NVP and intermediate resistance to EFV. |
