Figure 1.

Panel A, Time course of body weight measured over 10 weeks of nicotine treatment in mice fed an NCD or HFD. By 10 weeks of combined treatment with nicotine and HFD, mean body weight was significantly (P < .05) reduced relative to mice fed an HFD and saline. Panel B, Average food intake in mice fed an NCD or HFD in the absence or presence of nicotine. Panel C, Plasma FFA levels in various treatment groups. Panels D and E, Addition of nicotine to HFD also caused a significant increase in muscle triglyceride levels (panel D) and muscle oxidative stress as indicated by a low GSH to GSSG ratio (panel E). Values are given as mean ± SE of 5–6 mice per group. Means with different letters are significantly (P < .05) different from each other. Means with the same letter are not different.