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. 2014 Jan 7;155(3):663–669. doi: 10.1210/en.2013-1763

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Copyright © 2014 by The Endocrine Society

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Figure 4. — Hormonal regulation of miR-29b in LM A, Schematics of hormone treatment protocol. Hosts were ovariectomized (OVX) and supplemented with E2+P4 pellets at the time of grafting. After 4 weeks, pellets were removed. At 8 weeks, mice were treated with no hormone, E2, or E2+P4 for 2 weeks. The experiment was repeated using 4 different LM tissues. B, Volume change in LM xenografts. Tumor volumes are shown as the mean ± SD. C and D, E2+P4 down-regulates miR-29b and up-regulates collagens. The levels of mature miR-29b (C) and collagen mRNAs (D) were reversely correlated in LMs. *, P < .05; **, P < .01.