Figure 5.

NDRG1 deficiency modulates fetal serum cholesterol. (A) Mean fetal:maternal ratio of serum cholesterol concentration. *, P = .001 by Student's t test compared with WT and Het. Note also that hypoxia caused a universal reduction in fetal:maternal serum cholesterol ratio (P < .001 by multivariable linear regression). The numbers (n) below the bars denote the number of embryos analyzed for each paradigm. Standard (Std) and Hypoxia (Hpx) conditions are as described in Figure 2. (B) Total cholesterol content in placental tissue (n = 3). Standard (Std) and Hypoxia (Hpx) conditions are as described in Figure 2. (C) Fetal serum cholesterol (proportional to maximum value within litter) correlates with embryo weight; pairwise correlation coefficient 0.2542, P = .0016.