Table 1. Published breast cancer studies that screened the CDH1 gene for germline mutations in cases with no family history of gastric cancer.

Studies	Phenotypes	Mutation carriers	Total cases
Current study	Bilateral LCIS/ILC	4	50
	FH of breast cancera	2	27
	Early onset (<45 years)	2	7
	Bilateral LCIS/ILC	4	50
Rahman et al, 2000	LCIS	0	65
	FH of breast cancer	0	20
	Early onset (<45 years)	0	Unknown
	Bilateral LCIS	0	17
Masciari et al, 2007	9 ILC/14 mixed pathology	1	23
	FH of breast cancer	1	19
	Early onset (<45 years)	1	4
	Bilateral ILC	Unknown	Unknown
Schrader et al, 2011	ILC	0	318
	FH of breast cancer	0	104
	Early onset (<45 years)	0	214
	Bilateral ILC	0	Unknown
Xie et al, 2011	Familial ILCb	2	2
	FH of breast cancer	2	2
	Early onset (<45 years)	1	1
	Bilateral ILC	2	2

Abbreviations: ILC=invasive lobular breast cancer; LCIS=lobular carcinoma in situ.

^aNot confined to first-degree relative.

^bIndex case only described, Family A, 5 ILC cases, 2 bilateral; Family B, 1 ILC.