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. 2014 Jan 14;110(4):1045–1052. doi: 10.1038/bjc.2013.794

Figure 7.

Figure 7

PI3K mutations were observed in 35.3% (12/34) tumours. Overall exons 9 and 20, 10 PI3K mutations are exclusive of all other mutations (5/exon 9 and 5/exon 20), seven are found in TNBC-like with E545K mutation. H1047R mutations are distributed between both the tumour profiles. Braf mutations were observed in 13.8% (4/29) cases, two are exclusive of all other mutations and are distributed between both tumour profiles. HER-2 mutations were detected in 5.9% cases (2/34), one is exclusive of all other mutations and is found in TNBC-like. One classified TNBC-like patient has concomitant mutations for Braf and PI3K and another one for Braf, PI3K and HER-2. In total 66.6% (10/15) of TNBC-like are significantly (P<0.044) mutated compared with 26.3% (5/19) of the TNBC. No EGFR and Kras mutation was detected. wt: Wild type; Association between qualitative variables was assessed with Fisher's exact test.