Table 3. Risk of ovarian cancer by parity using generalised estimating equations and conditional logistic regression among women in the Breast Cancer Family Registry.
Conditional logistic |
GEE |
GEE |
|||
---|---|---|---|---|---|
Cases with unaffected sister controls |
Cases with unaffected sister controls |
All cases and all controls |
|||
|
Age-adjusted model |
Multivariable modela |
Age-adjusted model |
Multivariable modelb |
Multivariable modelc |
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
No. of full-term births | |||||
0 | Ref | Ref | Ref | Ref | Ref |
1 | 1.58 (0.45, 5.53) | 1.23 (0.23, 6.45) | 1.52 (0.53, 4.42) | 1.21 (0.30, 4.97) | 1.64 (0.96, 2.81) |
⩾2 |
0.97 (0.35, 2.65) |
0.50 (0.12, 2.12) |
1.21 (0.63, 2.34) |
0.96 (0.40, 2.27) |
2.30 (1.52, 3.48) |
Age at first birth (years) | |||||
Nulliparous | Ref | Ref | Ref | Ref | Ref |
<22 | 0.97 (0.31, 3.11) | 0.62 (0.13, 3.01) | 1.27 (0.61, 2.62) | 0.82 (0.31, 2.15) | 2.72 (1.76, 4.20) |
22–27 | 1.20 (0.41, 3.46) | 0.67 (0.15, 2.92) | 1.38 (0.67, 2.87) | 1.00 (0.40, 2.55) | 2.30 (1.49, 3.53) |
>27 |
1.05 (0.31, 3.56) |
0.70 (0.14, 3.37) |
1.04 (0.48, 2.25) |
1.22 (0.42, 3.52) |
1.40 (0.86, 2.27) |
Breastfeeding | |||||
Never | Ref | Ref | Ref | Ref | Ref |
Ever | 0.77 (0.31, 1.94) | 1.72 (0.54, 5.43) | 0.86 (0.50, 1.49) | 1.57 (0.77, 3.20) | 0.81 (0.61, 1.06) |
Abbreviations: CI=confidence interval; GEE=generalised estimating equation approaches; OR=odds ratio.
Adjusted for age, breastfeeding, age at menarche, height.
Adjusted for age, oral contraceptive use, age at first birth, age at last birth, breastfeeding, age at menarche, height.
Adjusted for age, oral contraceptive use, age at first birth, breastfeeding.