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Schematic of progesterone receptor structure and select phosphorylation sites. Progesterone receptor (PR) isoforms A and B differ in their inclusion of an N-terminal upstream segment unique to PR-B. Both isoforms contain an identical DNA binding domain (DBD), hinge region (H) and hormone binding domain (HBD). Full-length PR-B contains 14 phosphorylation sites; serines 81, 294, 345 and 400 have known links to PR action and gene expression in breast cancer.
