Table 3.
Results of significant 1 allele substitution effects P-value
|
Trait |
|
SNP
2
|
|
Estimate ± SE
3
|
P-values |
FDR
4
|
|---|---|---|---|---|---|---|
| Fatty acid | Common name | Lab Id | rs# | P-values | ||
|
Polyunsaturated fatty acids | ||||||
| C18:2n9c11t |
CLA:9c11t |
FADS2-19 |
rs210169303 |
-0.0176 ± 0.0083 |
0.036 |
0.248 |
| C18:2n10t12c |
CLA:10t12c |
FADS2-19 |
rs210169303 |
-0.0012 ± 0.0005 |
0.010 |
0.069 |
| C18:2n6cc |
Linoleic acid |
FADS1-07 |
rs42187261 |
-0.0410 ± 0.0197 |
0.038 |
0.137 |
| |
|
FADS1-08 |
rs41652284 |
-0.0468 ± 0.0226 |
0.039 |
0.137 |
| C18:2n6tt |
Trans linoleic acid |
FADS1-07 |
rs42187261 |
0.0069 ± 0.0033 |
0.036 |
0.126 |
| |
|
FADS2-19 |
rs210169303 |
-0.0083 ± 0.0034 |
0.016 |
0.109 |
| C20:3n6 |
Dihomogamma linolenic acid |
FADS1-01 |
rs136261927 |
-0.0087 ± 0.0021 |
0.000 |
0.0004 |
| |
FADS1-07 |
rs42187261 |
0.0037 ± 0.0017 |
0.032 |
0.055 |
|
| |
FADS1-08 |
rs41652284 |
-0.0044 ± 0.0020 |
0.027 |
0.055 |
|
| |
|
FADS2-23 |
rs109772589 |
-0.0080 ± 0.0021 |
0.0002 |
0.001 |
| C20:4n6 |
Arachidonic acid |
FADS1-07 |
rs42187261 |
0.0042 ± 0.0016 |
0.009 |
0.032 |
| |
|
FADS2-23 |
rs109772589 |
-0.0071 ± 0.0020 |
0.0004 |
0.003 |
| C20:5n3 |
Eicosapentaenoic acid |
FADS1-07 |
rs42187261 |
0.00420 ± 0.0008 |
0.0036 |
0.039 |
|
Monounsaturated fatty acids | ||||||
| C14:1 t |
Myristelaidic acid |
FADS2-05 |
rs211263660 |
0.0092 ± 0.0046 |
0.047 |
0.256 |
| C18:1n9c |
Oleic acid |
FADS1-07 |
rs42187261 |
-0.7529 ± 0.2889 |
0.009 |
0.067 |
| C18:1 total |
|
FADS1-07 |
rs42187261 |
-0.7697 ± 0.3023 |
0.011 |
0.079 |
| Total MUFA |
|
FADS1-07 |
rs42187261 |
-0.8044 ± 0.3445 |
0.020 |
0.141 |
|
Saturated fatty acids | ||||||
| C6:0 |
Caproic acid |
FADS1-07 |
rs42187261 |
0.0215 ± 0.0110 |
0.050 |
0.353 |
| C8:0 |
Caprylic acid |
FADS1-07 |
rs42187261 |
0.0246 ± 0.0108 |
0.023 |
0.158 |
| C10:0 |
Caprinic acid |
FADS1-07 |
rs42187261 |
0.087 2 ± 0.0382 |
0.023 |
0.161 |
| C11:0 |
Undecanoic acid |
FADS1-07 |
rs42187261 |
0.0111 ± 0.0041 |
0.008 |
0.053 |
| C12:0 |
Lauric acid |
FADS1-07 |
rs42187261 |
0.1249 ± 0.0525 |
0.018 |
0.125 |
| C16:0 |
Palmitic acid |
FADS1-01 |
rs136261927 |
0.6519 ± 0.3287 |
0.048 |
0.084 |
| |
|
FADS1-07 |
rs42187261 |
0.5063 ± 0.2555 |
0.048 |
0.084 |
| |
|
FADS2-05 |
rs209202414 |
-0.5908 ± 0.2473 |
0.017 |
0.079 |
| |
|
FADS2-19 |
rs210169303 |
0.6281 ± 0.2746 |
0.023 |
0.079 |
| C23:0 |
Tricosanoic acid |
FADS1-07 |
rs42187261 |
0.0021 ± 0.0008 |
0.006 |
0.044 |
| Total SFA | FADS1-07 | rs42187261 | 0.8069 ± 0.3549 | 0.024 | 0.165 | |
1For significant associations, P-values and FDR P-values (P≤0.05) are shown. Reference genotype is either CC or GG.
2Lab Id = lab notation of SNPs, rs# = SNP data base identification number of SNPs.
3Estimate = g/100 g of total fat, SE = Standard error.
4FDR = False discovery rate.