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. 2013 Oct 17;3(1):64–72. doi: 10.1016/j.molmet.2013.10.001

Figure 4.

Figure 4

AgRP neuronal expression of GHSR restores fasting glucagon levels and increases fasting-induced liver gluconeogenesis. (A) Fasting glucagon levels are restored in male GHSR-null/AgRP-CreERT2 mice with tamoxifen administration (mean±SEM, n=8–14 per group). (B) Fasting insulin levels are similar for all genotypes (mean±SEM, n=8–14 per group). (C) Expression of hepatic gluconeogenesis genes after overnight fasting, as determined using qRT-PCR, is increased in male GHSR-null/AgRP-CreERT2 mice with tamoxifen injection (mean±SEM, n=4–8 per group). ∧P=0.07; *P<0.05.