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. 2013 Dec 5;3(1):73–80. doi: 10.1016/j.molmet.2013.10.007

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Leptin deficiency upregulates the reward value of sucrose. (a and b) Leptin deficiency by treatment withdrawal rapidly reverses changes in daily food intake (statistics imbedded in text). (c) ob/ob;Chr2+ mice, but not ob/ob;Chr2− mice, were sensitive to the rewarding effect of optogenetic activation of DA neurons after leptin treatment withdrawal. ob/ob;Chr2+, but not ob/ob;Chr2− mice, preferred to lick the sipper coupled to laser stimulation of DA neurons. (d) Both ob/ob;Chr2+ and control ob/ob;Chr2− mice preferred sucrose to sucralose coupled to laser stimulation of DA neurons 48 h after leptin treatment withdrawal (statistics imbedded in text). Bars are mean±SEM, ^⁎⁎p<0.0012.