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. Author manuscript; available in PMC: 2014 Feb 20.
Published in final edited form as: Science. 2011 Dec 23;334(6063):1731–1734. doi: 10.1126/science.1214592

Fig. 1.

Fig. 1

Chronic Flx treatment before fear conditioning leads to fear erasure when combined with extinction training. (A) Flx treatment started 3 weeks before and continued throughout the experiment. (B) Control and Flx groups (n = 31 to 34 mice per group) exhibited similar levels of fear acquisition (extinction day 1, first block of 2 CS) and extinction (extinction day 2, last block of 2 CS). One week later (n = 21 per group) only control group showed spontaneous recovery and fear renewal. In the fear renewal test, the Flx-extinction group froze less than either control-extinction or Flx–no-extinction group (NoExt, n = 5). *P < 0.05, **P < 0.01, ***P < 0.001. Error bars indicate mean ± SEM.