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. Author manuscript; available in PMC: 2014 Feb 20.
Published in final edited form as: Science. 2011 Dec 23;334(6063):1731–1734. doi: 10.1126/science.1214592

Fig. 4.

Fig. 4

BDNF regulates fear memory erasure. (A) Chronic Flx after fear conditioning increased the BDNF exon-1 and total BDNF mRNA levels in the BLA and BDNF exon-1 level in the hippocampus (HIP) but not in the prefrontal cortex (mPFC). N = 6 to 8 per group. (B) Flx prevented fear renewal in BDNF+/+ mice (see protocol I, Fig. 2A) but failed to erase fearful memory in BDNF+/− mice. N = 10 or 11 per group. (C) BDNF-virus experiment: After successful fear acquisition and extinction, doxycycline treatment was terminated to induce BDNF overexpression in amygdala, which resulted in a significant reduction in freezing level in the fear renewal test. N = 6 or 7 per group. *P < 0.05, **P < 0.01, *** P < 0.001 versus control groups. Error bars indicate means ± SEM.