Table 4.
Accuracy of Lung-Cancer Classification According to Alternative Criteria in the PLCO Intervention-Group Smokers.*
| Criteria† | Participants with Lung Cancer (N = 678) | Participants without Lung Cancer (N = 36,654) | Total Participants (N = 37,332) | Predictive Value |
|---|---|---|---|---|
| NLST | ||||
| Criteria positive | 482 TP (3.4%) | 13,662 FP (96.6%) | 14,144 | PPV, 3.4% |
| Criteria negative | 196 FN (0.8%) | 22,992 TN (99.2%) | 23,188 | NPV, 99.2% |
| Sensitivity | 71.1% | |||
| Specificity | 62.7% | |||
| PLCOM2012 ‡ | ||||
| Criteria positive | 563 TP (4.0%) | 13,581 FP (96%) | 14,144 | PPV, 4.0% |
| Criteria negative | 115 FN (0.5%) | 23,073 TN (99.5%) | 23,188 | NPV, 99.5% |
| Sensitivity | 83.0% | |||
| Specificity | 62.9% |
*
FN denotes false negative, FP false positive, NPV negative predictive value, PPV positive predictive value, TN true negative, and TP true positive.
†
NLST criteria for study entry included a history of cigarette smoking of at least 30 pack-years and, for former smokers, cessation within the previous 15 years.
‡
According to the PLCOM2012 criteria, positivity was defined as a probability of lung cancer that was greater than 1.3455% over a period of 6 years.