Table 1.

Odds ratio for offspring depression according to each 5 point (1 s.d) increase in antenatal and postnatal depression scores (n=2847 complete cases all variables). Model 1) univariable, 2) adjusting for later maternal depression, 3) including confounding variables, 4) whilst adjusting for the other timing and 5) whilst excluding women exceeding thresholds at the other timing.

Timing of maternal depression	Model 1: Univariable associations between each timing of maternal depression and caseness of depression at 18.	Model 2: Model 1 with adjustments for exceeding thresholds ( >12) on the most recent maternal depression measure available (age 12)	Model 3: Model 1 including confounding* variables ( see figure note)	Model 4: Model 1 with adjustments for the other timing of maternal depression	Model 5: Model 1excluding women exceeding thresholds for depression at the other timing
Pregnancy	OR 1.28(95% CI 1.08 to 1.51) p=0.003	OR 1.27 (95% CI 1.08 to 1.51) p=0.003	OR 1.23 (95% CI 1.03 to 1.44) p=0.025	OR 1.27 (95% CI 1.02 to 1.59) p=0.035 (adjusted for postnatal depression)	OR 1.29 (95% CI 1.08 to 1.55) p=0.006 (excluding women with postnatal depression ) n=2778
Postnatal	OR 1.24 (95% CI 1.03 to 1.49) p=0.022	OR 1.21(95% CI 1.01 to 1.44) p=0.034	OR 1.13 (95% CI 0.94 to 1.34) p=0.188	OR 0.98 (95% CI 0.77 to 1.23) p=0.857 (adjusted for antenatal depression)	OR 1.20 (95% CI 0.98 to 1.48) p=0.081 (excluding women with antenatal depression) n=2272

^*Confounding variables; maternal age, parity, social class, maternal education, maternal history of depression, smoking during pregnancy, child gender, breastfeeding in the first year and child-care.