Table 2.
Multivariate poisson regression models for death in 3 separate TB groups.
| TB meningitis | Pulmonary TB | Extrapulmonary TB | |||||||
|---|---|---|---|---|---|---|---|---|---|
| aIRR** | 95% CI | P | aIRR | 95% CI | P | aIRR | 95% CI | P | |
| Region | |||||||||
| East versus other | 5.41 | 2.58–11.34 | <0.0001 | 2.87 | 1.62–5.08 | 0.0003 | 11.32 | 7.35–17.44 | <0.0001 |
| On cART at TB | |||||||||
| Yes versus no | 0.25 | 0.11–0.58 | 0.0013 | 0.38 | 0.17–0.82 | 0.014 | 0.38 | 0.21–0.69 | 0.0016 |
| Prior AIDS at TB | |||||||||
| Yes versus no | 4.82 | 2.61–8.92 | <0.0001 | 0.92 | 0.57 – 1.49 | 0.74 | 1.55 | 1.07–2.25 | 0.022 |
| Multidrug resistant | |||||||||
| Yes versus no | 0.30 | 0.06–1.43 | 0.13 | 1.72 | 0.75–3.94 | 0.20 | 0.71 | 0.22–2.29 | 0.57 |
| Rifamycin in initial regimen | |||||||||
| Yes versus no | 1.18 | 0.62–2.23 | 0.62 | 0.81 | 0.48–1.35 | 0.42 | 0.85 | 0.61–1.18 | 0.32 |
| Disseminated | |||||||||
| Yes versus no | 2.12 | 0.88–5.13 | 0.095 | ∗ | ∗ | ∗ | 1.42 | 0.83–2.42 | 0.20 |
| CD4 at TB | |||||||||
| ≤200 cells/mm3 | 1.00 | 0.52–1.92 | 0.99 | 1.99 | 1.15–3.43 | 0.014 | 2.40 | 1.65–3.50 | <0.0001 |
| >200 cells/mm3 | 1.00 | — | — | 1.00 | — | — | 1.00 | — | — |
| Unknown | 0.54 | 0.23–1.20 | 0.17 | 1.27 | 0.78–2.08 | 0.34 | 1.90 | 1.27–2.84 | 0.0019 |
| Age | |||||||||
| Per 10 yr older | 0.81 | 0.60–1.10 | 0.18 | 0.89 | 0.68–1.15 | 0.37 | 1.07 | 0.90–1.27 | 0.24 |
| Diagnosis | |||||||||
| Definitive versus presumptive/probable | 1.33 | 0.74–2.37 | 0.34 | 0.86 | 0.54–1.37 | 0.53 | 0.72 | 0.53–0.97 | 0.033 |
*No patients with disseminated disease in pulmonary TB group.
**The adjusted incidence rate ratios (aIRRs) were adjusted for all other variables in the model.
Tests for interaction: TB type *region (P = 0.0004), TB type *on cART at TB (P = 0.90), TB type *AIDS (P = 0.0003), TB type *MDR (P = 0.28), TB type *rifamycin in regimen (P = 0.13), TB type *CD4 (P = 0.028), TB type *age (P = 0.73), TB type *diagnosis type (P = 0.74), and TB type *disseminated disease (P = 0.83).