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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Nat Rev Drug Discov. 2013 Apr;12(4):265–286. doi: 10.1038/nrd3955

Table 3. Human adenosine receptors.

Receptor
name		 Human
gene		 Chromosome G proteins Localization Potency of
adenosine*
Adenosine A1
receptor		 ADORA1 1q32.1 Gi,o Broad distribution:
high in nerves, heart,
kidney and adipose tissue		 10−8 to 10−7
Adenosine A2A
receptor		 ADORA2A 22q11.23 Gs/olf Broad distribution:
very high in basal ganglia;
high in nerves, blood
vessels and immune cells		 10−8 to 10−7
Adenosine A2B
receptor		 ADORA2B 17p12-p11.2 Gs (Gq/11; G12/13) Broad distribution, but
generally low abundance		 3 × 10−7 to 10−5
Adenosine A3
receptor		 ADORA3 1p13.2 Gi/o Restricted distribution,
varying in different
species: high in mast cells		 10−8 to 10−7
*

The potency (in mol per l) is determined by the effect of the agonist in cells expressing approximately 2 × 105 receptors per cell; see REF. 1 for details.