Table 3.
Associations between tagging SNPs in LINGO1 and LINGO2 with ET and PD
| Essential tremor (n =1247)
|
Parkinson disease (n=633)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| SNP (MA) | Dominant
|
Recessive
|
Dominant
|
Recessive
|
||||
| LINGO1 | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value |
| rs4886887 (A) | 0.91 (0.74, 1.13) | 0.41 | 1.83 (1.11, 3.01) | 0.018 | 0.95 (0.75, 1.21) | 0.70 | 1.41 (0.80, 2.49) | 0.23 |
| rs3144 (G) | 0.94 (0.77, 1.15) | 0.52 | 1.48 (1.05, 2.08) | 0.030 | 1.01 (0.80, 1.26) | 0.96 | 1.25 (0.85, 1.85) | 0.26 |
| rs3743481 (T) | 1.03 (0.84, 1.27) | 0.78 | 1.08 (0.82, 1.42) | 0.59 | 1.05 (0.83, 1.32) | 0.70 | 1.06 (0.78, 1.44) | 0.72 |
| rs907396 (C) | 1.03 (0.83, 1.27) | 0.80 | 1.04 (0.78, 1.41) | 0.78 | 1.00 (0.78, 1.27) | 0.98 | 0.95 (0.67, 1.33) | 0.74 |
| rs907400 (G) | 1.05 (0.84, 1.31) | 0.70 | 1.29 (0.64, 2.58) | 0.48 | 0.98 (0.76, 1.26) | 0.85 | 0.72 (0.30, 1.70) | 0.45 |
| rs11856978 (C) | 1.09 (0.85, 1.40) | 0.51 | 1.45 (0.56, 3.77) | 0.45 | 0.96 (0.72, 1.28) | 0.77 | 1.50 (0.52, 4.28) | 0.45 |
| rs7162113 (T) | 1.10 (0.90, 1.35) | 0.37 | 1.24 (0.77, 1.99) | 0.37 | 0.93 (0.74, 1.18) | 0.56 | 0.89 (0.51, 1.54) | 0.67 |
| rs13329256 (T) | 1.02 (0.76, 1.39) | 0.88 | 2.73 (0.31, 24.12) | 0.37 | 0.81 (0.57, 1.16) | 0.25 | 4.74 (0.52, 42.95) | 0.17 |
| rs9652490a (C) | 0.95 (0.77, 1.16) | 0.61 | 0.63 (0.42, 0.95) | 0.026 | 1.00 (0.79, 1.25) | 0.98 | 0.54 (0.33, 0.89) | 0.016 |
| rs8028808 (T) | 0.97 (0.78, 1.20) | 0.76 | 0.49 (0.29, 0.83) | 0.008 | 1.00 (0.78, 1.27) | 0.97 | 0.59 (0.32, 1.08) | 0.08 |
| rs11855874 (C) | 1.12 (0.89, 1.41) | 0.33 | 1.03 (0.49, 2.15) | 0.95 | 0.89 (0.68, 1.16) | 0.37 | 1.14 (0.52, 2.50) | 0.75 |
| rs4886893 (A) | 0.95 (0.78, 1.17) | 0.66 | 1.10 (0.63, 1.93) | 0.73 | 0.88 (0.70, 1.11) | 0.29 | 1.19 (0.65, 2.19) | 0.57 |
| rs4886894 (C) | 0.86 (0.70, 1.05) | 0.14 | 1.00 (0.70, 1.41) | 0.98 | 0.88 (0.70, 1.10) | 0.27 | 1.08 (0.74, 1.59) | 0.68 |
| rs12898861(A) | 1.15 (0.93, 1.43) | 0.20 | 1.14 (0.88, 1.47) | 0.32 | 1.01 (0.80, 1.29) | 0.91 | 1.24 (0.94, 1.64) | 0.13 |
| rs4243047 (A) | 0.95 (0.77, 1.16) | 0.59 | 0.85 (0.64, 1.14) | 0.27 | 0.90 (0.72, 1.13) | 0.37 | 0.81 (0.58, 1.12) | 0.20 |
| rs12905478 (G) | 0.88 (0.69, 1.13) | 0.31 | 0.36 (0.16, 0.86) | 0.021 | 1.00 (0.76, 1.31) | 0.97 | 0.76 (0.33, 1.73) | 0.51 |
| LINGO2 | ||||||||
| rs10968215 (A) | 1.02 (0.83, 1.25) | 0.87 | 1.14 (0.81, 1.61) | 0.45 | 0.97 (0.77, 1.23) | 0.81 | 0.88 (0.59, 1.32) | 0.53 |
| rs9644872 (C) | 1.19 (0.96, 1.47) | 0.12 | 1.02 (0.79, 1.32) | 0.89 | 0.96 (0.76, 1.22) | 0.75 | 0.91 (0.68, 1.21) | 0.51 |
| rs13362909 (A) | 1.37 (0.99, 1.90) | 0.06 | 1.84 (0.36, 9.25) | 0.46 | 1.10 (0.76, 1.60) | 0.62 | 2.76 (0.55, 14.01) | 0.22 |
| rs10757699 (C) | 1.07 (0.87, 1.31) | 0.55 | 0.97 (0.73, 1.28) | 0.83 | 0.88 (0.70, 1.11) | 0.30 | 0.81 (0.59, 1.12) | 0.21 |
| rs7854367 (A) | 0.84 (0.66, 1.07) | 0.15 | 1.27 (0.74, 2.20) | 0.39 | 0.97 (0.74, 1.26) | 0.79 | 1.57 (0.88, 2.80) | 0.13 |
| rs4880001 (G) | 1.03 (0.83, 1.27) | 0.79 | 1.12 (0.85, 1.47) | 0.43 | 1.04 (0.82, 1.32) | 0.76 | 0.91 (0.66, 1.25) | 0.56 |
| rs10968280 (T) | 0.82 (0.64, 1.04) | 0.11 | 1.85 (0.72, 4.73) | 0.20 | 0.73 (0.55, 0.97) | 0.029 | 1.28 (0.42, 3.87) | 0.66 |
| rs11793421 (G) | 0.92 (0.72, 1.16) | 0.47 | 0.94 (0.39, 2.29) | 0.90 | 1.24 (0.96, 1.61) | 0.10 | 1.97 (0.82, 4.70) | 0.13 |
| rs10812774 (A) | 0.92 (0.73, 1.16) | 0.46 | 0.90 (0.70, 1.16) | 0.40 | 0.89 (0.69, 1.15) | 0.37 | 0.95 (0.72, 1.26) | 0.71 |
| rs16912763 (A) | 0.82 (0.64, 1.06) | 0.12 | 1.31 (0.50, 3.44) | 0.59 | 1.06 (0.80, 1.40) | 0.68 | 0.99 (0.31, 3.10) | 0.98 |
| rs1331866 (T) | 1.08 (0.85, 1.36) | 0.55 | 1.37 (0.59, 3.17) | 0.46 | 0.83 (0.63, 1.09) | 0.18 | 1.41 (0.56, 3.56) | 0.47 |
| rs13296489 (C) | 1.03 (0.81, 1.30) | 0.81 | 0.82 (0.64, 1.05) | 0.12 | 0.95 (0.73, 1.23) | 0.67 | 0.97 (0.74, 1.27) | 0.81 |
| rs10968542 (A) | 1.00 (0.81, 1.24) | 1.00 | 0.95 (0.73, 1.23) | 0.70 | 0.99 (0.78, 1.26) | 0.94 | 0.99 (0.74, 1.33) | 0.95 |
| rs16912778 (G) | 1.22 (0.99, 1.51) | 0.06 | 1.30 (0.99, 1.72) | 0.06 | 0.96 (0.76, 1.22) | 0.76 | 1.25 (0.92, 1.71) | 0.15 |
| rs2026376 (T) | 1.12 (0.84, 1.51) | 0.44 | 0.49 (0.17, 1.47) | 0.21 | 1.03 (0.74, 1.44) | 0.86 | 0.45 (0.12, 1.77) | 0.25 |
| rs10757744 (C) | 1.05 (0.82, 1.33) | 0.72 | 0.65 (0.32, 1.34) | 0.24 | 0.99 (0.76, 1.30) | 0.94 | 0.81 (0.37, 1.77) | 0.59 |
| rs1412229 (T) | 1.08 (0.86, 1.35) | 0.52 | 0.72 (0.55, 0.94) | 0.015 | 0.81 (0.63, 1.03) | 0.09 | 0.87 (0.65, 1.17) | 0.35 |
| rs4879257 (T) | 0.90 (0.73, 1.10) | 0.30 | 0.73 (0.48, 1.11) | 0.14 | 1.09 (0.86, 1.38) | 0.47 | 0.78 (0.48, 1.26) | 0.30 |
| rs7033345 (G) | 0.85 (0.70, 1.04) | 0.12 | 0.76 (0.52, 1.12) | 0.17 | 1.06 (0.85, 1.33) | 0.61 | 0.83 (0.54, 1.28) | 0.39 |
| rs1438478 (C) | 0.81 (0.63, 1.04) | 0.10 | 0.94 (0.44, 2.02) | 0.87 | 0.99 (0.75, 1.30) | 0.93 | 0.73 (0.29, 1.84) | 0.50 |
| rs6476092 (G) | 0.91 (0.74, 1.12) | 0.39 | 0.71 (0.45, 1.11) | 0.13 | 1.09 (0.87, 1.38) | 0.45 | 0.72 (0.43, 1.21) | 0.21 |
Odd ratios (OR), 95% confident intervals (CI), and P values were obtained from logistic regression models adjusted for age and gender MA, minor allele
a
Includes 428 control subjects, 353 ET, and 426 PD patients previously reported [9]