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Simulated (areas) and observed (solid circles, lines) free and total cefazolin concentrations versus time as predicted by the empirical model (a) and semiphysiological model (b) for trimesters 2 and 3 of pregnancy. Simulations are represented as the parametric 95% confidence intervals of the simulated 50th (red), 5th, and 95th (blue) percentiles. For the observed values, the 50th (continuous line), 5th, and 95th (dashed lines) percentiles are depicted in red.
