Table 3.

Parameter estimates of the nonlinear mixed effect model for change in creatinine clearance (CrCL).

Description	Parameter	Unit	Estimates (RSE%)
Structural model estimates as reported in a previous meta-analysis (13)
Baseline CrCL	CrCL0	mL/min	97.83 (3.91)*
Maximum CrCL	CrCLMAX	—	83.83 (12.48)*
Time of half-maximum CrCL	CrCL50	weeks	13.3 (37.59)*
Between subject variability (CV%)
Baseline CrCL	ω CrCL0	CV%	31.4 (16)
Maximum CrCL	ω CrCLMAX	CV%	35.1 (17)
Time of half-maximum CrCL	ω CrCL50	CV%	111.8 (121)
Residual unexplained variability variance
Proportional error	σ CrCL		0.0291 (43)

CrCL: creatinine clearance; RSE: relative standard error. *These values were fixed during estimation of the mixed effect model; that is, only random effects were estimated.