Table 1.
Descriptive values per center reported as median (interquartile range IQR).
| Amsterdam | London | |
|---|---|---|
| Nr. patients (women) | 10 (4) | 10 (5) |
| Age (years) median (IQR) | 44 (32–48) | 34 (30–44) |
| Disease typea | 9 RRMS, 1 SPMS | 10 RRMS |
| Disease duration (years) median (IQR) | 8 (8–9) | 2 (1.5-2.5) |
| EDSSb | 1.5 (1–4.25) | 1.5 (1–2) |
| Disease modifying treatment | 5 patients | - |
| NBV on gold-standard filled images (L)c median (IQR) | 1.43 (1.48-1.53) | 1. 54 (1.48-1.58) |
| Lesion load (mL) median (IQR)d | 1.2 (0.52-4.55) | 6.27 (2.21-15.99) |
| Lesion numbers median (IQR)d | 21 (16–40) | 15 (10–22) |
| 3DT1 hypointense lesion volume (mL) median (IQR) | 1.55 (0.9-4.3) | 6 (2–11.1) |
| 3DT1 hypointense lesion numbers median (IQR) | 20 (16–42) | 15 (9–31) |
| Field strength (T) | 3.0 | 1.5 |
| 3D-T1 voxel size (mm) | Sagittal 0.97/0.97/1 | Axial 1.17/1.17/1.5 |
| PDT2 voxel size (mm) | 0.5/0.5/3 | 0.9/0.9/5 |
a
RRMS = relapsing-remitting multiple sclerosis SPMS = secondary progressive multiple sclerosis.
b
EDSS = Expanded Disability Status Scale.
c
NBV = Normalized Brain Volume (calculated with FSL-SIENAX).
d
Lesion load (lesion numbers) = lesion volume (lesion numbers) on the 2DT2 lesion masks that had already been manually outlined for the original study in the participating centers.