Table 2.
Summary of phenotypes in whole-lung cells of bleomycin (BLM)- or BLM + pirfenidone-treated mice determined through fluorescence-activated cell sorter analysis in a therapeutic setting *
|
Percentage of cells |
|||
---|---|---|---|---|
Treatment | CD45-/Col-I- | CD45+/Col-I- | CD45-/Col-I+ | CD45+/Col-I + (Fibrocyte) |
Saline |
64.8 ± 9.5 |
9.76 ± 13.6 |
15.3 ± 21.4 |
10.1 ± 1.7 |
BLM |
25.1 ± 3.0 |
16.1 ± 22.0 |
33.1 ± 25.0 |
25.6 ± 5.9 |
BLM + pirfenidone | 47.8 ± 7.2 | 6.8 ± 8.7 | 27.8 ± 7.8 | 17.6 ± 6.4 |
*Data are shown as the percentage of cells that are positive (+) or negative (−) for CD45 or collagen I (Col-I) in whole-lung cells. Data shown represent the means ± standard error from 6 saline-, BLM- or BLM + pirfenidone-treated mice, respectively, and are representative of 2 independent experiments.