Table 2.
Functional annotation and transcriptional regulation patterns of the prognostic relevant signature.
| Feature no. | Gene symbol | Regulated by MYB |
Regulated by MYBL1 & L2 |
Biological function(s) and/or cancer-related activities |
|---|---|---|---|---|
| 2654 | APOM | Up | — | Protein |
| 714 | IQCK | Up | Down | SRC-3 binding protein |
| 9472 | POU2F1 | Up | Down | TF |
| 20014 | PPP1R9A | Up | — | Phosphatase |
| 11991 | POU2F1 | Up | Down | TF |
| 7164 | ZFP112(ZNF228) | Up | Down | Zinc finger protein |
| 4051 | TMC5 | Up | Down | Transmembrane channel-like protein |
| 9673 | STK36 | Up | Down | Serine/threonine kinase |
| 1509 | TMEM87B(CR621710) | Up | — | Transmembrane protein |
| 6481 | TTC19 | Up | Down | Roles in protein-protein interactions |
| 10396 | BC009926 | Up | Down | The inner mitochondrial membrane protein |
| 20295 | PAH | Up | — | amino acid metabolism |
| 3096 | SALL2 | Up | — | TF and putative tumor suppressor |
| 17750 | TBC1D9 | Up | Down | Multidrug resistance gene 1(MDR1) |
| 20917 | NTN4 | Up | Down | Good prognostic factor |
| 8570 | CATSPER2 | Up | — | Ion channel |
| 6691 | ANAPC4 | Up | Down | Chromosome replication |
| 10334 | THSD4 | Up | Down | A disintegrin and metalloproteinase |
| 9326 | ABAT | Up | Down | Aminotransferase |
| 15762 | NBPF4(ENST00000370040) | Up | — | Undefined function |
| 10024 | XBP1 | Up | Down | TF |
| 10998 | PMS2CL | Up | — | Mismatch repair gene |
| 11119 | TGM2 | Down | — | Metabolism |
| 3069 | ACOT7 | Down | Up | Fatty acid metabolism |
| 1039 | GNAI2 | Down | — | G protein |
| 19802 | PKMYT1 | Down | Up | Kinase |
| 20037 | GAPDH | Down | Up | Candidate target for cancer treatment; proliferation and metastasis; glycolysis. |
| 5918 | MAP1S | Down | — | Morphology; microtubule associated protein |
| 956 | CCDC124 | Down | Up | Undefined function |
| 21198 | GNB2 | Down | — | G protein |
| 13619 | TOMM40 | Down | — | Enzyme |
| 18840 | NFKBIL2 | Down | — | A negative regulator of NFKB mediated transcription; the maintenance of genome stability; may cause chemoresistance |
| 4681 | RAB42 | Down | Up | Putative Ras-related protein related to cell proliferation |
| 3891 | MAF1 | Down | Up | Control transcription initiation |
| 21760 | ZNF598 | Down | Up | Undefined function |
| 17698 | EIF5A | Down | — | Translation |
| 7939 | SLC25A1 | Down | Up | Cellular component |
| 7824 | PCBP3 | Down | — | Posttranscriptional activities |
| 16475 | DUSP7 | Down | Up | Phosphatase |
| 17776 | PICK1 | Down | — | Signaling molecule; poor prognosis; promote tumor growth |
| 3073 | RANGAP1 | Down | Up | G protein signaling; a new target for cancer chemotherapy |