Table 1:
Details of included studies
| Investigators (year of publication) | Design | n | Time point of fibrinogen determination (method) | Clinical characteristics | Outcome measurements |
|---|---|---|---|---|---|
| Blome et al. (2005) | Case–control | 98 | Preoperative Postoperative (Clauss) |
Divided into three groups of BL; lower, mid and high tertile Low (I): median 400 ml (150–475) High (III): median 1050 ml (700–2550) |
BL <12 and 24 h FGN median (10th and 90th percentiles) EE: P-value |
| Bolliger et al. (2008) | Case– control | 197 | Preoperative Postoperative (not reported) |
CABG surgery PEBL: >1000 ml/24 h Non-PEBL: <1000 ml/24 h |
BL <12 and 24 h FGN range EE: correlation |
| Davidson et al. (2008) | Case–control | 58 | Postoperative (Clauss-like) | Primary CABG surgery PEBL >200 ml/h <4 h (n = 8): median BL 787 ml vs non-PEBL (n = 50): median BL 150 ml |
BL <4 h FGN median (range) EE: P-value |
| Essell et al. (1993) | Case–control | 36 | Postoperative (not reported) | All cardiac surgical patients | BL and BT <24 h EE: P-value |
| Faraday et al. (2002) | Cohort | 57 | Postoperative (Clauss-like) | Elective CABG, (multiple) valve replacement, ascending aortic aneurysm repair and combined valve–CABG proceduresa | BL <24 and BT <24 h FGN OR EE: correlation |
| Fassin et al. (1991) | Case–control | 107 | Postoperative (not reported) | CABG surgery Group I (n = 70): <1000 ml/24 h vs Group II (n = 33): >1000 ml/24 h |
BL <24 h and BT FGN mean (SD) EE: mean differences |
| Gravlee et al. (1994) | Case–control | 897 | Postoperative (Clauss-like) | Elective and emergent cardiac surgery PEBL: BL >1000 ml/16 h vs non-PEBL: BL <1000 ml/16 h |
BL <16 h and BT FGN mean (SD) EE: correlation |
| Hall et al. (2002) | Case–control | 82 | Postoperative (Clauss-like) | Elective and emergent cardiac surgery The cases with BL requiring re-exploration (n = 82, = 200 ml/h 4 h or sudden rise BL <2 h) and controls selected randomly (n = 478) | BL <18–24 h FGN EE: P-value |
| Josefy et al. (2011) | Cohort | 35 | Preoperative (Clauss-like) | Patients undergoing CABG surgery not taking clopidogrela | BT; RBCs, platelets, FFPs and cryoprecipitated AHF FGN EE: correlation |
| Karkouti et al. (2010) | Cohort | 101 | Postoperative (not reported) | Complex cardiac surgery (other than isolated CABG, single valve surgery or repair of atrial septal defect) Median BL 952 ml/24 h | BL <24 h FGN mean (SD) EE: correlation |
| Karlsson et al. (2008) | Cohort | 170 | Preoperative (Clauss) | CABG surgery. Median BL 360 ml/12 h | BL <12 h and BT during admission FGN mean (SD) EE: correlation |
| Liu et al. (2000) | Cohort | 46 | Preoperative Postoperative (not reported) |
Primary CABG surgery. Median BL 825 ml/24 h | BL <24 h FGN (correlation) EE: correlation |
| Marengo-Rowe et al. (1979) | Case–control | 774 | Postoperative (not reported) | CABG surgery PEBL >600 ml/8 h (n = 164) vs non-PEBL <600 ml/8 h (n = 610) |
BL <8 h EE: P-value |
| Nuttall et al. (1997) | Case–control | 82 | Postoperative (Clauss) | CABG, valve replacement or repair, or congenital heart surgery PEBL (n = 30): median BL 949 ml vs non-PEBL (n = 52): median BL 547 ml |
BL and BT <24 h FGN mean (SD) EE: correlation |
| Ozolina et al. (2011) | Case–control | 124 | Preoperative Postoperative (not reported) |
Cardiac surgerya Group I: <500 ml/24 h Group II: >500 ml/24 h |
BL <24 h EE: correlation |
| Prohaska et al. (2008) | Cohort | 2831 | Preoperative (Clauss-like) | CABG surgery, aortic valve replacement, combined CABG and aortic valve replacement, and other single or combined cardiac proceduresa | BT; RBCs, FFPs and PCs perioperative and <2 days FGN mean (SD) EE: OR |
| Ternström et al. (2010) | Cohort | 59 | Preoperative Postoperative (Clauss) |
Elective CABG. Median postoperative BL 380 ml/12 h | BL <12 h EE: correlation |
| Ucar et al. (2007) | Cohort | 97 | Preoperative (Clauss) | All cardiac surgical patients | BL <48 h FGN mean (SD) EE: correlation |
| Wahba et al. (1997) | Case–control | 89 | Postoperative (Clauss) | Primary CABG surgery PEBL (n = 14):1.650 ± 280 ml vs non-PEBL (n = 75): 780 ± 250 ml |
BL until removal of drains (usually Day 1) FGN mean (SD) EE: correlation |
| Welsby et al. (2006) | Cohort | 32 | Postoperative (Clauss-like) | CABG or valve operations | BL <4 h FGN mean (SD) EE: correlation |
BL: blood loss; FGN: fibrinogen; EE: effect estimate; PEBL: patients with excessive blood loss; Clauss-like: automated, probably Clauss-like, coagulation method; BT: blood transfusions; OR: odds ratio.
aCPB usage was not mandatory for study inclusion.