Table I.

Gene profiling of BAL cells from CR vs. CS asthma

Classification	Affymetrix U133 + 2.0	Gene Accession#	Mean CR asthma±SE*	Mean CS asthma±SE*	Fold induction in CR/CS asthma (MAS 5.0)	Fold induction in CR/CS asthma (RMA)
Molecules associated with classical pattern of macrophage activation
IL-6	205207_at	NM_000600	8199±2183	231±52	35.54†	34.22†
TNF alpha	207113_s_at	NM_000594	4640±593	431±114	10.76†	8.9†
IL-1 beta	205067_at	NM_000576	20205±6204	1947±351	10.38†	7.38†
IL-1 alpha	210118_s_at	M15329	8921±4015	1053±327	8.47†	6.5†
CCL20	205476_at	NM_004591	15591±3047	580±56	26.90†	21.7†
CXCL8 (IL-8)	202859_x_at	NM_000584	30651±1958	2014±837	15.22†	24.05†
CCL3	205114_s_at	NM_002983	6374±2466	752±184	8.48†	11.09†
CXCL3	207850_at	NM_002090	20093±5258	2590±569	7.72†	4.92†
CCL4	204103_at	NM_002984	9648±747	1372±277	7.03†	5.89†
CXCL2	209774_x_at	M57731	22556±2913	3738±1174	6.03†	7.35†
CXCL1	204470_at	NM_001511	663±161	117±19	5.66†	7.34†
Molecules associated with alternative pattern of macrophage activation
CCL24	221463_at	NM_00299	330±58	2388±290	0.14†	0.16†
arginase 1	231662_at	AV652232	9±10	37±18	absent	absent
LPS/TNF related signaling molecules
early growth response 1	227404_s_at	AI459194	39963±13583	2696±299	14.82†	12.45†
molecule possessing ankyrin repeats induced by LPS (MAIL)	223217_s_at	BE646573	23852±4436	3040±1170	7.85†	7.15†
dual specificity phosphatase 2	204794_at	NM_004418	1643±83	212±18	7.73†	10.52†
TNF alpha-induced protein 3	202643_s_at	AI738896	11911±4214	1849±389	6.44†	4.92†

^*Mean signal intensity±SEM of three BAL samples from CR asthmatics and three BAL samples from CS asthmatics

^†p<0.05 comparing data sets from CR asthma vs. CS asthma groups analyzed with two-tailed unpaired t test