Table II.
Gene profiling of BAL cells from CR vs. CS asthma by real-time PCR
Classification | Mean CR asthma±SE* | Mean CS asthma±SE* | Fold induction in CR/CS asthma | P value |
---|---|---|---|---|
IL-6 | 503±172 | 7.2±1.9 | 69.9 | 0.0007 |
CXCL8 (IL-8) | 2740±847 | 10.4±1.6 | 263.5 | 0.0006 |
CCL3 | 25.9±9.1 | 4.2±1.7 | 6.2 | 0.0379 |
CXCL3 | 14.2±3.3 | 3.8±1.3 | 3.74 | 0.0175 |
CCL4 | 13.2±5.8 | 3.3±1.3 | 4.0 | 0.0379 |
CXCL2 | 13.2±3.5 | 4.1±1.2 | 3.22 | 0.0530 |
CXCL1 | 8.4±4.0 | 2.5±1.3 | 3.36 | 0.1282 |
early growth response 1 | 14.8±3.9 | 2.2±0.6 | 6.73 | 0.0006 |
molecule possessing ankyrin repeats induced by LPS (MAIL) | 10.5±3.5 | 2.8±0.8 | 3.75 | 0.0262 |
dual specificity phosphatase 2 | 34.3±17.0 | 0.8±0.4 | 42.88 | 0.0041 |
TNF alpha-induced protein 3 | 11911±4214 | 1849±389 | 2.37 | 0.0379 |
Mean signal intensity±SEM ng of the target mRNA/ng 18s RNA of 7 additional BAL samples from CR asthmatics and 7 additional BAL samples from CS asthmatics