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Activation of ERK1/2, p38and PI3K/Akt induced by epidermal growth factor (EGF). The levels of total p38 MAPK and phosphorylated p38 MAPK (phospho-p38) (A), total ERK1/2 and phosphorylated ERK1/2 (phospho-ERK1/2) (B), and total Akt and phosphorylated Akt (phospho-Akt) (C) in HepG2 and HCCLM3 measured by Western blot, the average level of three identical experiments (n = 3 each). Starved cells were challenged without (0) or with EGF at doses of 10, 50 and 100 ng/ml.
