Fig 8.
Inhibitory effects on phosphorylation of Akt and Erk. Total and phosphorylated Akt (A) and Erk1/2 (B) in HepG2 cells and total and phosphorylated Akt (C) and Erk1/2 (D) in HCCLM3 cells treated with vehicle (DMSO), erlotinib (EGFRI), U0126, BEZ235 and SHBM1009 (SHBM) and stimulated with vehicle or epidermal growth factor at 100 ng/ml.