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. 2014 Jan 28;18(2):253–262. doi: 10.1111/jcmm.12228

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Copyright © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig 5 — Lung specimens from controls (A–C and G) and patients with systemic sclerosis (SSc) (D–F and H). (A–F) CD34 immunoperoxidase labelling with haematoxylin counterstain. (G and H) Double immunofluorescence labelling for CD34 (green) and CD31 (red) with DAPI (blue) counterstain for nuclei. (A–C) In control lung parenchyma, telocytes are broadly distributed in the interstitial space around alveoli and bronchioles. Telocytes also encircle blood vessels (inset in A) and are located around smooth muscle bundles within the wall of bronchioles (inset in B). At higher magnification view, lung telocytes display a slender nucleated body and two long varicose processes extending in the pulmonary interstitium (inset in C). (D–F) In the fibrotic lung of SSc patients, very few or no telocytes are observed in the thickened alveolar septa and in the interstitial space surrounding terminal and respiratory bronchioles, around blood vessels (inset in D) and smooth muscle bundles within the wall of bronchioles (inset in E). (G and H) Pulmonary telocytes are CD34-positive and CD31-negative, while vascular endothelial cells are CD34/CD31-double-positive. Inset: Higher magnification view of a telocyte with two long cellular extensions. TB: terminal bronchiole. Scale bars are indicated in each panel.