Table 2. Patient Demographic and Tumor Characteristics by Stage at Diagnosis of Cutaneous Melanoma With Corresponding Univariate Odds Ratios (ORs) and 95% Confidence Intervals (CIs), SEER 1973-2006 (n = 192,014).
| Stage at Diagnosis | Earlya | Lateb | Crude OR (95% CI) | Pc |
|---|---|---|---|---|
| Demographic Variable | n (%)d | |||
| Marital status at diagnosis | <.0001 | |||
| Married | 121,008 (71.9) | 14,983 (63.0) | 1.00 (reference) | |
| Single (never married) | 22,318 (13.3) | 3684 (15.5) | 1.33 (1.28, 1.39) | |
| Divorced or separated | 10,500 (6.2) | 2003 (8.4) | 1.54 (1.46, 1.62) | |
| Widowed | 14,411 (8.6) | 3107 (13.1) | 1.74 (1.67, 1.82) | |
| Sex | <.0001 | |||
| Female | 75,518 (44.9) | 8816 (37.1) | 1.00 (reference) | |
| Male | 92,719 (55.1) | 14,961 (62.9) | 1.38 (1.34, 1.42) | |
| Age, y | <.0001 | |||
| 18-24 | 3269 (1.9) | 438 (1.8) | 1.00 (referent) | |
| 25-39 | 22,263 (13.2) | 2505 (10.5) | 0.84 (0.75, 0.94) | |
| 40-54 | 42,827 (25.5) | 5560 (23.4) | 0.97 (0.87, 1.08) | |
| 55-69 | 49,001 (29.1) | 6743 (28.4) | 1.03 (0.93, 1.14) | |
| 70 or older | 50,877 (30.2) | 8531 (35.9) | 1.25 (1.13, 1.39) | |
| Race | <.0001 | |||
| White | 166,383 (98.9) | 23,080 (97.1) | 1.00 (reference) | |
| Black | 616 (0.4) | 303 (1.3) | 3.55 (3.09, 4.07) | |
| Othere | 1238 (0.7) | 394 (1.7) | 2.29 (2.05, 2.57) | |
| Year of diagnosis | <.0001 | |||
| 1973-1979 | 6879 (4.1) | 1440 (6.1) | 1.00 (reference) | |
| 1980-1989 | 19,007 (11.3) | 2910 (12.2) | 0.73 (0.68, 0.78) | |
| 1990-1999 | 43,525 (25.9) | 6093 (25.6) | 0.67 (0.63, 0.71) | |
| 2000-2006 | 98,826 (58.7) | 13,334 (56.1) | 0.65 (0.61, 0.68) | |
| Tumor histology | <.0001 | |||
| Lentigo maligna melanoma | 27,681 (16.5) | 429 (1.8) | 1.00 (reference) | |
| Superficial spreading (SS) | 47,018 (28.0) | 3323 (14.0) | 4.56 (4.12, 5.05) | |
| Nodular | 7250 (4.3) | 4692 (19.7) | 41.8 (37.7, 46.3) | |
| Acral lentiginous (AL) | 1179 (0.7) | 507 (2.1) | 27.7 (24.1, 32.0) | |
| Other or unspecified | 85,109 (50.6) | 14,826 (62.4) | 11.2 (10.2, 12.4) | |
| Anatomical site | <.0001 | |||
| Upper limb and shoulder | 40,411 (24.0) | 3927 (16.5) | 1.00 (reference) | |
| Lower limb and hip | 30,455 (18.1) | 4430 (18.6) | 1.50 (1.43, 1.57) | |
| Trunk | 51,831 (30.8) | 5909 (24.9) | 1.17 (1.12, 1.22) | |
| Head and neck | 44,670 (26.6) | 4744 (20.0) | 1.09 (1.05, 1.14) | |
| Overlapping lesion of the skin | 166 (0.1) | 29 (0.1) | 1.80 (1.21, 2.67) | |
| Skin, not otherwise specified | 704 (0.4) | 4738 (19.9) | 69.3 (63.6, 75.5) | |
| Socioeconomic statusf,g | Mean (SD) | |||
| Median household incomeh | 45.9 (12.0) | 44.4 (11.7) | 0.95 (0.94, 0.95)i | <.0001 |
| Below poverty (%) | 8.3 (4.2) | 8.7 (4.5) | 1.11 (1.09, 1.13)j | <.0001 |
| Unemployed (%) | 6.0 (2.1) | 6.1 (2.2) | 1.20 (1.16, 1.24)j | <.0001 |
| Urban (%) | 88.3 (18.6) | 86.6 (20.5) | 0.96 (0.95, 0.96)k | <.0001 |
| Less than high school education (%) | 18.9 (6.8) | 19.6 (7.1) | 1.07 (1.06, 1.08)j | <.0001 |
| White collar (%) | 37.0 (5.8) | 36.4 (5.8) | 0.84 (0.82, 0.86)k | <.0001 |
Early stage is in situ or localized stage using SEER summary staging.
Late stage is regional or distant stage using SEER summary staging.
P values are from a global univariate likelihood ratio test.
Percentages may not add to 100.0% due to rounding.
Other includes American Indian, Alaska Native, Asian/Pacific Islander, and other race, unspecified.
Socioeconomic variables are proxy measures for each individual and represent the county-level median or percentage for the county of residence.
Fourteen patients were missing data about socioeconomic variables; thus, the sample size was 192,000 for those variables.
In thousands of 2000 US dollars.
OR represents an increase in median household income of $5000.
OR represents an absolute 5% increase.
OR represents an absolute 10% increase.