Appendix Table 2.

Inter-relationship of the Change in Cardiometabolic Variables and Composite Risk Scores

	IGF-1	Free T	Total LBM	Total Fat	Trunk Fat	Extrem. Fat	BMI	QUICKI	Triglycerids	SBP	HDL-Chol	Adiponectin	SHBGf	CRCSg
Tesosterone	0.18	0.92	0.39	−0.39	−0.28	−0.47	0.03	−0.07	−0.11	−0.13	−0.17	−0.48	0.06	0.16
P value	0.06	<.001	<.001	<.001	0.003	<.001	0.72	0.46	0.26	0.18	0.07	<.001	0.56	0.10
IGF-1		0.25	0.40	−0.33	−0.31	−0.27	0.10	−0.02	−0.08	0.06	−0.14	−0.15	0.03	0.12
P value		.008	<.001	<.001	<.001	0.004	0.30	0.81	0.42	0.52	0.15	0.11	0.72	0.21
Free T.			0.44	−0.37	−0.28	−0.44	0.11	−0.12	−0.09	−0.12	−0.12	−0.41	0.06	0.19
P value			<.001	<.001	.003	<.001	0.27	0.20	0.34	0.22	0.20	<.001	0.50	0.05
LBMa				−0.43	−0.38	−0.40	0.59	−0.02	0.03	−0.02	−0.24	−0.34	0.09	0.25
P value				<.001	<.001	<.001	<.001	0.86	0.77	0.86	0.01	<.001	0.34	.008
Total Fat					0.93	0.83	0.47	−0.22	0.19	−0.06	0.06	0.15	−0.20	0.23
P value					<.001	<.001	<.001	0.02	0.04	0.54	0.56	0.13	0.04	0.02
Trunk Fat						0.57	0.46	−0.17	0.18	−0.03	0.02	0.08	−0.21	0.28
P value						<.001	<.001	0.07	0.06	0.78	0.80	0.42	0.03	.003
Extrem. Fat							0.34	−0.21	0.17	−0.10	0.10	0.21	−0.11	0.07
P value							<.001	0.03	0.08	0.31	0.30	0.02	0.26	0.44
BMIb								−0.21	0.19	−0.07	−0.19	−0.20	−0.09	0.45
P value								0.03	0.04	0.47	0.05	0.03	0.26	<.001
QUICKIc									−0.31	0.11	−0.05	−0.02	0.15	−0.49
P value									0.001	0.26	0.64	0.85	0.12	<.001
Tryglcerides										−0.14	0.05	0.13	−0.07	0.34
P value										0.14	0.61	0.16	0.49	<.001
Systolic BPd											−0.02	0.07	−0.19	0.21
P value											0.83	0.47	0.05	0.03
HDL-Chol												0.17	0.14	−0.41
P value												0.08	0.14	<.001
Adiponectine													0.06	−0.33
P value													0.51	<.001
SHBG														−0.34
P value														<.001

^aLean body mass

^bBody mass index

^cQualitative insulin sensitivity check index

^dBlood pressure

^eHigh molecular weight adiponectin component

^fSex hormone binding globulin

^gCardiometabolic risk composite score