Table II.
Multivariate model for reduced 5-year survival following CEA for asymptomatic stenosis
| Covariate | HR | 95% CI | P value |
|---|---|---|---|
| Age, years | |||
| <70 | Referent | - | - |
| 70-79 | 1.8 | 1.4-2.2 | <.001 |
| ≥80 | 3.94 | 3.0-5.1 | <.001 |
| Diabetes | |||
| Nondiabetic | Referent | - | - |
| Diet or oral medication controlled | 1.34 | 1.1-1.7 | .008 |
| Insulin dependent | 1.98 | 1.5-2.7 | <.001 |
| Past or current smoking history | 1.68 | 1.3-2.2 | <.001 |
| CHF | 1.78 | 1.4-2.3 | <.001 |
| COPD | 1.66 | 1.4-2.0 | <.001 |
| Renal function | |||
| eGFRa ≥ 60 | Referent | - | - |
| eGFRa < 60 | 1.30 | 1.1-1.6 | .007 |
| Dialysis dependent | 3.41 | 1.6-7.2 | .001 |
| Not on statin | 1.27 | 1.1-1.6 | .021 |
| Degree of contralateral ICA stenosis | |||
| <50% | Referent | - | - |
| 50%-80% | 1.25 | 1.1-1.5 | .032 |
| >80%-99% | 1.95 | 1.3-2.9 | .001 |
| Occluded | 1.69 | 1.2-2.4 | .002 |
CEA, Carotid endarterectomy; CHF, congestive heart failure; CI, confidence interval; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; HR, hazard ratio; ICA, internal carotid artery.
a
eGFR in mL/min.