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. 2014 Feb 20;10(2):e1003479. doi: 10.1371/journal.pcbi.1003479

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© 2014 Hünniger et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Time-dependent increase of C. albicans association with blood cells as determined by flow cytometry. The majority of C. albicans cells associated to PMN whereas only low interactions could be observed for monocytes and no association to lymphocytes was detectable. The percentages of C. albicans associated with PMN (striped bars) or monocytes (black bars) were calculated relative to total C. albicans cells in blood (set to ). All values correspond to the means of five independent experiments with whole blood from five different donors. (B) Representative blood smears of C. albicans-infected blood after (a), (b), (c) and (d) demonstrate continuous filamentation of extracellular fungi (I). Ingested C. albicans (black arrows) were mainly found in PMN and showed different morphotypes. (C) Survival assay of C. albicans exposed to human whole blood shows a rapid killing of the fungus within of infection. Each dot represents C. albicans colony forming units (C. a. CFU/ml blood) of independent experiments with blood from different donors. The mean standard deviation is given for each time point.

Inline graphic — (A) Time-dependent increase of C. albicans association with blood cells as determined by flow cytometry. The majority of C. albicans cells associated to PMN whereas only low interactions could be observed for monocytes and no association to lymphocytes was detectable. The percentages of C. albicans associated with PMN (striped bars) or monocytes (black bars) were calculated relative to total C. albicans cells in blood (set to ). All values correspond to the means of five independent experiments with whole blood from five different donors. (B) Representative blood smears of C. albicans-infected blood after (a), (b), (c) and (d) demonstrate continuous filamentation of extracellular fungi (I). Ingested C. albicans (black arrows) were mainly found in PMN and showed different morphotypes. (C) Survival assay of C. albicans exposed to human whole blood shows a rapid killing of the fungus within of infection. Each dot represents C. albicans colony forming units (C. a. CFU/ml blood) of independent experiments with blood from different donors. The mean standard deviation is given for each time point.