Figure 4. Types of transition in the state-based model.
Illustration of all types of transitions, arranged according to their effect on C. albicans. Circular symbols depict different states and arrows represent transitions between states. Each transition type is associated with a specific transition rate. Extracellular alive C. albicans can be extracellularly killed by antimicrobial effector molecules, i.e. transition from state 
to 
, with rate 
. Alive as well as killed C. albicans can become resistant C. albicans, i.e. transition from state 
to state 
and transition from state 
to state 
, with transition rate 
. Furthermore, alive and dead extracellular C. albicans can be phagocytosed by monocytes with rate 
and by PMN that phagocytose for the first time or at least for the second time with rate 
and 
, respectively. Alive C. albicans that were already phagocytosed can be killed intracellular in monocytes with transition rate 
as well in PMN with rate 
. The monocytes and PMN containing 
alive and 
killed C. albicans are represented by 
and 
, respectively.