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. 2014 Feb 20;10(2):e1004175. doi: 10.1371/journal.pgen.1004175

Figure 8. A model for activation of the SUP-9 channel by multiple subunits.

Figure 8

In this model, SUP-10 and UNC-93 act independently of SUP-18 to activate SUP-9. In addition, SUP-10 enhances SUP-18, which activates SUP-9 through a distinct pathway. SUP-10(n983gf) over-enhances SUP-18, which over-activates SUP-9 and leads to paralysis. The widths of the arrows pointing at SUP-9 are representative of their relative strengths in sustaining gf activity, with thicker arrows representing a larger contribution.